Achieve Organ-Specific Responses Requirement for Elevated Cell Input to TCR Transfer Model and Reveals a Neonatal Immunity Develops in a Transgenic
نویسندگان
چکیده
منابع مشابه
Evaluation of Specific Purified TCR Effect on the Immunoregulatory Potential of TGF-beta
Transforming growth factor beta (TGF-b) is a mediator released by nearly all cell types. It has suppression activity on the immune system, but exactly how this effect is carried out is not clear. Previous experiments showed that IgG interacts with or carriers active TGF-b, that could suppresses cytotoxic T-cell responses to an immunogenic tumor in mice. Since T cell receptor (TCR) has structura...
متن کاملPhysiological and Pathological Roles for MicroRNAs: Implications for Immunity Complications
MicroRNAs (miRNAs) are small non-coding regulatory RNAs molecules with a size of approximately 22 nucleotides that are implicated in regulating gene expression at the post-transcriptional regulatory levels. Inflammatory disorders especially autoimmune diseases (ADs) occur from an abnormal immune response of body against cells of their own specific tissues or multiple organ systems leading to ch...
متن کاملRetraction: Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells.
We reported previously that tumor-specific CD8(+) T cells (TcR-I) become tolerant in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. In this study, we show that CD4(+) TcR transgenic (TcR-II) T cells transferred into TRAMP mice became activated in lymph nodes, trafficked to the prostate, and initially functioned as T(H)1 cells. Although a single cotransfer of TcR-II cells del...
متن کاملModulation of Immunoglobulin Production by Invariant Vα19-Jα33 TCR-Bearing Cells
We have previously shown that invariant Vα19-Jα33 TCR(+) (Vα19i T) cells suppress the disease progress in some models for organ specific autoimmune diseases and type IV allergy that deteriorate along with decline to excess in Th1- or Th17- immunity. In this study, we examined the effects of over-generation of Vα19i T cells on the Th2-controlled immunoglobulin isotype production in the models fo...
متن کاملInduction of Immune Response in Animal Model Using Recombinant Anti-NDV Vaccine
Background: Newcastle disease is a major avian disease that causes enormous economic loss in poultry industry. There have been a number of reports on the suitability of plant-based recombinant vaccine against this disease. Fusion (F) and hemagglutinin-neuraminidase (HN) epitopes of the Newcastle disease virus (NDV) represent the major immunogenic sites for development of recomb...
متن کامل